If you change the directory that Interspire Email Marketer resides in you then must update the 'admin/includes/config.php' file.
Edit the line:
define('SENDSTUDIO_APPLICATION_URL', 'http://www.domain.com/iem');
To point to the new folder.
If you have cron set up to run on your server you will need to update it with the new path to your cron file. This can be found in the settings page.

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