If you have Interspire Email Marketer installed on a separate domain to your main website, then Captcha will not work in Safari.
By default, Safari's security settings are set to only trust the website you are visiting.
Since Interspire Email Marketer is on a separate website to the one you are visiting, Interspire Email Marketer cannot set a cookie to remember the Captcha code.
When you submit the form, Interspire Email Marketer cannot verify the code because it could not remember it in the first place.
The only options are to disable Captcha on the form, or change your Safari Security Settings.
To do that, go to the "Safari" menu on a Mac or "Edit" menu on a PC, choose "Preferences".
Choose the "Security" tab and change "Accept Cookies" to "Always".

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