There is no real difference in how you set up your bounces. It is merely personal preference.
If you wish to keep your bounces completly separate then you can set up different bounce accounts. This can be helpful if you have different clients using the application so that the bounces go to @domain.com for the domain.com client and to example.com for the example.com client.
If you do not mind your bounces all arriving at the same location then you can set up the one account and send all emails to this account.
If you expect to have a lot of bounces, say you are sending to 3 lists of 500,000 contacts then it could be an idea to keep the bounce accounts separate so that they do not fill up and cause problems.

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